Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;1(2):72-6.
doi: 10.4103/2279-042X.108374.

Serum adenosine deaminase in patients with rheumatoid arthritis treated with methotrexate

Mansour Salesi  1 , Rozita Aghaye Ghazvini  1 , Ziba Farajzadegan  2 , Mansoor Karimifar  1 , Hadi Karimzadeh  1 , Maryam Masoumi  3 , Bahareh Ebrahimi  4
Affiliations

Serum adenosine deaminase in patients with rheumatoid arthritis treated with methotrexate

Mansour Salesi et al. J Res Pharm Pract. 2012 Oct.

Abstract

Objective: Recently, adenosine deaminase (ADA) is introduced as helpful marker in diagnosis, prognosis, and monitoring of treatment in rheumatoid arthritis (RA). The aim of this study was to determine the efficacy of the serum ADA in diagnosis, prognosis, and monitoring of treatment with methotrexate (MTX) in RA.

Methods: This was a self-controlled clinical trial conducted in university hospitals of Isfahan, Iran. The serum level of ADA, erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) were measured for 70 patients with active RA (Disease Activity Score-28 [DAS28] > 3/2). After three months of MTX treatment and disease remission (DAS28 < 2.6) these markers were measured again. ANCOVA multiregression and paired t-test were used to compare and evaluate the mean level and correlation of ADA, ESR, IgM-RF, and DAS before and after RA remission.

Findings: The mean value for ADA activity was significantly higher than the normal one compared with other studies. Significant decreases were seen in values of ADA, ESR, RF, visual analogue scale (VAS), and DAS after remission. Also, the correlation coefficient between the values of ADA with ESR and DAS were statistically significant in baseline. Moreover, the statistically significant correlation between ADA and ESR, VAS, and DAS were seen after remission. No correlation was found in the case of the dosage of MTX with the value of ADA.

Conclusion: It was concluded that ADA may be considered useful as a marker in diagnosis, prognosis, and monitoring of treatment with Methotrexate in RA.

Keywords: Adenosine deaminase; disease activity score; methotrexate; rheumatoid arthritis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: Nil.

Figures

None
The CONSORT diagram of the clinical trial
See this image and copyright information in PMC

References

    1. Samanta R, Shoukrey K, Griffiths R. Rheumatoid arthritis and anaesthesia. Anaesthesia. 2011;66:1146–59. - PubMed
    1. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205–19. - PubMed
    1. Nalesnik M, Nikolic JM, Jandric S. Adenosine deaminase and C-reactive protein in diagnosing and monitoring of rheumatoid arthritis. Med Glas Ljek Komore Zenicko-Doboj Kantona. 2011;8:163–8. - PubMed
    1. Goronzy JJ, Matteson EL, Fulbright JW, Warrington KJ, Chang-Miller A, Hunder GG, et al. Prognostic markers of radiographic progression in early rheumatoid arthritis. Arthritis Rheum. 2004;50:43–54. - PubMed
    1. Yazici Y, Abramson SB. Rheumatoid arthritis treatment and monitoring of outcomes-where are we [corrected] in 2007? Bull NYU Hosp Jt Dis. 2007;65:300–5. - PubMed