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Case Reports
. 2013 Oct;2(4):169-71.
doi: 10.4103/2279-042X.128152.

Fixed drug eruption due to clarithromycin

Santoshi Balkrishna Malkarnekar  1 , L Naveen  1
Affiliations
Case Reports

Fixed drug eruption due to clarithromycin

Santoshi Balkrishna Malkarnekar et al. J Res Pharm Pract. 2013 Oct.

Abstract

Fixed drug eruption (FDE) is an unusual adverse effect of any drug, especially antibiotics like clarithromycin. Herein we report a case of clarithromycin induced FDE in a 30-year-old man who presented with recurrent erythematous and pruritic cutaneous lesions on the lower lip, right hand and left thigh. The lesions were initially misdiagnosed as lichen planus and treated with topical steroids. Each recurrence was at the same site and the lesions faded within 2 weeks leaving behind violacceous pigmentation. All the cutaneous lesions were reproduced following an oral provocation test thus confirming the diagnosis of clarithromycin induced FDE, which is a rare occurrence. When it does occur, it is often misdiagnosed, so physicians should be aware of this condition in order to prevent future recurrences as it causes a lot of cosmetic and physical discomfort to the patient.

Keywords: Clarithromycin; fixed drug eruption; oral provocation test.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Fixed drug eruption in the form of erythematous plaques on the dorsal aspect of the right index finger and the base of the right middle finger
Figure 2
Figure 2
Fixed drug eruption on the right corner of the lower lip
See this image and copyright information in PMC

References

    1. Hamamoto Y, Ohmura A, Kinoshita E, Muto M. Fixed drug eruption due to clarithromycin. Clin Exp Dermatol. 2001;26:48–9. - PubMed
    1. Rosina P, Chieregato C, Schena D. Fixed drug eruption from clarithromycin. Contact Dermatitis. 1998;38:105. - PubMed
    1. Alonso JC, Melgosa AC, Gonzalo MJ, García CM. Fixed drug eruption on the tongue due to clarithromycin. Contact Dermatitis. 2005;53:121–2. - PubMed
    1. Lee HJ, Kim HS, Park YM, Kim HO, Lee JY. Fixed drug eruption due to allopurinol: Positive oral provocation. Ann Dermatol. 2011;23:402–3. - PMC - PubMed
    1. Mahboob A, Haroon TS. Drugs causing fixed eruptions: A study of 450 cases. Int J Dermatol. 1998;37:833–8. - PubMed

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