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. 1989 Jun;91(6):682-7.
doi: 10.1093/ajcp/91.6.682.

Single-dose tetracycline labeling for bone histomorphometry

D J Sherrard  1 , N A Maloney
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Single-dose tetracycline labeling for bone histomorphometry

D J Sherrard et al. Am J Clin Pathol. 1989 Jun.

Abstract

A single oral dose of tetracycline deposits in bone and is readily identified with fluorescence microscopy. Two such time-spaced labels can be used to determine bone dynamic features. This is as accurate as conventional three-day labeling periods. The simplicity, improved compliance, and substantial reduction in time it takes to prepare a patient for bone biopsy all appear to be advantageous when compared with current recommendations.

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