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. 2014 Jul-Aug;37(4):108-10.
doi: 10.1097/WNF.0000000000000039.

Haplotype analysis of GSK-3β gene polymorphisms in bipolar disorder lithium responders and nonresponders

Kazuhiko Iwahashi  1 , Daisuke Nishizawa, Shin Narita, Maki Numajiri, Ohoshi Murayama, Eiji Yoshihara, Yuuya Onozawa, Kenta Nagahori, Fumihiko Fukamauchi, Kazutaka Ikeda, Jun Ishigooka
Affiliations
Free PMC article

Haplotype analysis of GSK-3β gene polymorphisms in bipolar disorder lithium responders and nonresponders

Kazuhiko Iwahashi et al. Clin Neuropharmacol. 2014 Jul-Aug.
Free PMC article

Abstract

The GSK-3β gene, GSK3B, codes for an enzyme that is a target for the action of mood stabilizers, lithium and possibly valproic acid.In this study, the relationship between haplotypes consisting of single nucleotide polymorphisms (SNPs) of GSK3B -50T/C and -1727A/T and the effect of lithium was studied among Japanese bipolar disorder lithium nonresponders and responders.The distributions of the GSK3B haplotypes (-50T/C and -1727A/T) showed a trend for significant difference between the lithium nonresponders and responders (global P=0.07074). Haplotype 1 (T-A) was associated with a higher lithium response (haplotype-specific P=0.03477), whereas haplotype 2 (C-A) was associated with a lower lithium response (haplotype-specific P=0.03443).The pairwise D' and r values between the 2 SNPs in this study were 1.0 and 0.097, respectively. The 2 SNPs showed weak linkage disequilibrium with each other.

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Figures

FIGURE 1
FIGURE 1
SNPs in the promoter region of the GSK-3β gene. Regulatory cis- elements for transcription are indicated according to the report of Lau et al (1999).
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