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Review
. 2015 Jan-Feb;11(1):33-40.
doi: 10.1016/j.reuma.2014.05.004. Epub 2014 Jul 1.

Genetics of osteoarthritis

[Article in English, Spanish]
Cristina Rodriguez-Fontenla  1 , Antonio Gonzalez  2
Affiliations
Free article
Review

Genetics of osteoarthritis

[Article in English, Spanish]
Cristina Rodriguez-Fontenla et al. Reumatol Clin. 2015 Jan-Feb.
Free article

Abstract

Osteoarthritis (OA) is a complex disease caused by the interaction of multiple genetic and environmental factors. This review focuses on the studies that have contributed to the discovery of genetic susceptibility factors in OA. The most relevant associations discovered until now are discussed in detail: GDF-5, 7q22 locus, MCF2L, DOT1L, NCOA3 and also some important findings from the arcOGEN study. Moreover, the different approaches that can be used to minimize the specific problems of the study of OA genetics are discussed. These include the study of microsatellites, phenotype standardization and other methods such as meta-analysis of GWAS and gene-based analysis. It is expected that these new approaches contribute to finding new susceptibility genetic factors for OA.

Keywords: Artrosis; Complex diseases; Enfermedades complejas; Estudios de asociación de genoma completo (GWAS); Genetics; Genome-wide association studies (GWAS); Genética; Osteoarthritis.

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