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Observational Study
. 2014 Jul 3:14:677.
doi: 10.1186/1471-2458-14-677.

Use of antibiotics in rural and urban regions in The Netherlands: an observational drug utilization study

Josta de Jong  1 , Jens H J Bos, Tjalling W de Vries, Lolkje T W de Jong-van den Berg
Affiliations
Observational Study

Use of antibiotics in rural and urban regions in The Netherlands: an observational drug utilization study

Josta de Jong et al. BMC Public Health. .

Abstract

Background: Large livestock farms might increase the infection risk for the nearby human population because of an increased risk for disease outbreaks and because antibiotic-resistant bacteria are more likely to be present. We hypothesized that populations residing in rural areas have more contact with cattle compared with populations in urban areas, and will use more antibiotics or more frequently require a new course of antibiotics.

Methods: Using data from the prescription database IADB.nl, we compared antibiotic use by patients living in rural areas to the use by patients living in urban areas. We also followed cohorts of antibiotic users and determined the patients who required a second antibiotic within 14 days after beginning the first antibiotic.

Results: The yearly prevalence of antibiotic use was greater in rural areas compared with urban areas (2009: 23.6% versus 20.2% (p < 0.001), especially in the younger age groups. More adult patients residing in rural areas required a second course of antibiotic treatment within 14 days after starting the first treatment.

Conclusion: Individuals use more antibiotics, and adults more frequently require a second antibiotic prescription within 14 days, in rural areas compared with urban areas. Although the differences were small and the risks for the general rural population were not high, this difference should be investigated further.

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Figures

Figure 1
Figure 1
Number of antibiotics prescriptions per person, per year, for the rural (degree of urbanization (DU) = 5) and the urban (DU = 1) populations.
See this image and copyright information in PMC

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References

    1. van der Meulen H, de Bont K, Agricola H, van Horne P, Hoste R, van der Knijff A, Leenstra F, van der Meer R, de Smet A. Schaalvergroting in de land- en tuinbouw. Effecten bij veehouderij en glastuinbouw. 2011.
    1. Smit LA, van der Sman-de BF, Opstal-van Winden AW, Hooiveld M, Beekhuizen J, Wouters IM, Yzermans J, Heederik D. Q fever and pneumonia in an area with a high livestock density: a large population-based study. PLoS One. 2012;7(6):e38843. - PMC - PubMed
    1. van Cleef BA, Verkade EJ, Wulf MW, Buiting AG, Voss A, Huijsdens XW, van Pelt W, Mulders MN, Kluytmans JA. Prevalence of livestock-associated MRSA in communities with high pig-densities in The Netherlands. PLoS One. 2010;5(2):e9385. - PMC - PubMed
    1. Mulders MN, Haenen AP, Geenen PL, Vesseur PC, Poldervaart ES, Bosch T, Huijsdens XW, Hengeveld PD, Dam-Deisz WD, Great EA, Mevius D, Voss A, Van De Giessen AW. Prevalence of livestock-associated MRSA in broiler flocks and risk factors for slaughterhouse personnel in The Netherlands. Epidemiol Infect. 2010;138(5):743–755. - PubMed
    1. Rijks Instituut voor Volksgezondheid en Milieu (National Institute for Public Health and Environment) WIP-richtlijnen MRSA, ziekenhuis. 2012. Available at: http://www.rivm.nl/dsresource?objectid=rivmp:46603&type=org&disposition=.... Accessed 09/18, 2012.

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