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. 1989 May 15;160(3):1243-9.
doi: 10.1016/s0006-291x(89)80137-8.

Oleate-induced translocation of protein kinase C to hepatic microsomal membranes

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Oleate-induced translocation of protein kinase C to hepatic microsomal membranes

L Boscá et al. Biochem Biophys Res Commun. .

Abstract

The incubation of rat liver homogenates in the presence of oleate induces the translocation of protein kinase C from the cytosol to the endoplasmic reticulum membranes. The half-maximal effect was obtained at 0.3 mM oleate. The redistribution of this enzyme induced by oleate was also obtained with purified protein kinase C and hepatic microsomal membranes. This effect seems to be mediated by long-chain fatty acids since translocation was not obtained with esterified derivatives.

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