Oleate-induced translocation of protein kinase C to hepatic microsomal membranes
- PMID: 2499326
- DOI: 10.1016/s0006-291x(89)80137-8
Oleate-induced translocation of protein kinase C to hepatic microsomal membranes
Abstract
The incubation of rat liver homogenates in the presence of oleate induces the translocation of protein kinase C from the cytosol to the endoplasmic reticulum membranes. The half-maximal effect was obtained at 0.3 mM oleate. The redistribution of this enzyme induced by oleate was also obtained with purified protein kinase C and hepatic microsomal membranes. This effect seems to be mediated by long-chain fatty acids since translocation was not obtained with esterified derivatives.
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