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Comment
. 2014 Jul 3;124(1):5-6.
doi: 10.1182/blood-2014-05-572917.

CDK6, a new target in MLL-driven leukemia

Iléana Antony-Debré  1 , Ulrich Steidl  1
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Comment

CDK6, a new target in MLL-driven leukemia

Iléana Antony-Debré et al. Blood. .
Free article

Abstract

In this issue of Blood, Placke et al identify the cell-cycle regulator CDK6 as a promising new target in mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML) and show that its downregulation or pharmacological inhibition leads to growth inhibition and differentiation of MLL-driven leukemic cells.

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  • Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
    Placke T, Faber K, Nonami A, Putwain SL, Salih HR, Heidel FH, Krämer A, Root DE, Barbie DA, Krivtsov AV, Armstrong SA, Hahn WC, Huntly BJ, Sykes SM, Milsom MD, Scholl C, Fröhling S. Placke T, et al. Blood. 2014 Jul 3;124(1):13-23. doi: 10.1182/blood-2014-02-558114. Epub 2014 Apr 24. Blood. 2014. PMID: 24764564 Free PMC article.

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