Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jun 19:5:187.
doi: 10.3389/fgene.2014.00187. eCollection 2014.

Firth logistic regression for rare variant association tests

Affiliations

Firth logistic regression for rare variant association tests

Xuefeng Wang. Front Genet. .
No abstract available

Keywords: GEE; association test; firth logistic regression; penalized likelihood; rare variants.

PubMed Disclaimer

References

    1. Firth D. (1993). Bias reduction of maximum likelihood estimates. Biometrika 80, 27–38 10.1093/biomet/80.1.27 - DOI
    1. Heinze G., Puhr R. (2010). Bias-reduced and separatio-proof conditional logistic regression with small or sparse data sets. Stat. Med. 29, 770–777 10.1002/sim.3794 - DOI - PubMed
    1. Heinze G., Schemper M. (2002). A solution to the problem of separation in logistic regression. Stat. Med. 21, 2409–2419 10.1002/sim.1047 - DOI - PubMed
    1. Ma C., Blackwell T., Boehnke M., Scott L. J. (2013). Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants. Genet. Epidemiol. 37, 539–550 10.1002/gepi.21742 - DOI - PMC - PubMed

LinkOut - more resources