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Review
. 2014 May;8(5):ZE07-10.
doi: 10.7860/JCDR/2014/8764.4355. Epub 2014 May 15.

Nanosurface - the future of implants

Affiliations
Review

Nanosurface - the future of implants

Gk Thakral et al. J Clin Diagn Res. 2014 May.

Abstract

Nanotechnology is a relatively newer field of science that is finding enormous scope in the dental & medical science. Use of endosseous dental implant surfaces having nano-scale topography is fast becoming part of modern implantology. The purpose of this review is to discuss and understand the role of nanoscale surface modification of titanium materials for the purpose of improving various phases of implantology including osseointegration. Nanotechnology equips bioengineers with newer ways of interacting with relevant biological processes. On the other hand, the field of nanotechnology provides means of understanding and achieving cell specific functions. An understanding of the role of nano-topography leads to the significant osseointegration modulations by nanoscale modification of the implants surface. Use of nanotechnology to modify the topography of titanium endosseous implant can drastically improve cellular and tissue responses that may benefit osseointegration and dental implant procedures.

Keywords: Dental implants; Nanotechnology; Osseointegration; Osteogenesis; Surface treatment; Topography.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
A cluster of titanium dioxide nanotubes
[Table/Fig-2]:
[Table/Fig-2]:
Bone cell anchoring to a surface of titanium dioxide nanotubes
[Table/Fig-4]:
[Table/Fig-4]:
Depiction of broad range of nano-scale topography effects observed in cellular protein adsorption in bulk materials. Both cell specificity and extent of cell adhesion are altered. Depending on the nano-architecture cell spreading may be increased or decreased
[Table/Fig-5]:
[Table/Fig-5]:
Nanoscale topography-cell interactions on a nano-surface produced by H2O2/H2SO4 treatment(A) 10,000_ image of adherent cell, (B) and (C) represent 100,000_images of the same adherent cell and (D) 200,000_ magnification of the cell with nano-features. (B) Higher magnification of the rectangle in (A). (D) Higher magnification of the rectangle in (B)

References

    1. Cooper LF. Biologic determinants of bone formation for osseointegration: clues for future clinical improvements. J Prosth Dent. 1998;80:439–49. - PubMed
    1. Nanci A, et al. Chemical modification of titanium surfaces for covalent attachment of biological molecules. J Biomed Mater Res. 1998;40:324–35. - PubMed
    1. Gutwein LG, Webster TJ. Increased viable osteoblast density in the presence of nanophase compared to conventional alumina and titania particles. IJ Biomaterials. 2004;25:4175–83. - PubMed
    1. Tolou Shokuhfar, et al. Intercalation of anti-inflammatory drug molecules within TiO2 nanotubes. JRSC Adv. 2013;3(38):17380–6.
    1. Silva GA. Introduction to nanotechnology and its application to medicine. J SurgNeurol. 2004;61:216–20. - PubMed

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