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Review
. 2014:2014:375423.
doi: 10.1155/2014/375423. Epub 2014 Jun 5.

Indole alkaloids from marine sources as potential leads against infectious diseases

Paulo H B França  1 , Daniel P Barbosa  2 , Daniel L da Silva  1 , Êurica A N Ribeiro  2 , Antônio E G Santana  1 , Bárbara V O Santos  3 , José M Barbosa-Filho  3 , Jullyana S S Quintans  4 , Rosana S S Barreto  4 , Lucindo J Quintans-Júnior  4 , João X de Araújo-Júnior  5
Affiliations
Review

Indole alkaloids from marine sources as potential leads against infectious diseases

Paulo H B França et al. Biomed Res Int. 2014.

Abstract

Indole alkaloids comprise a large and complex class of natural products found in a variety of marine sources. Infectious diseases remain a major threat to public health, and in the absence of long-term protective vaccines, the control of these infectious diseases is based on a small number of chemotherapeutic agents. Furthermore, the emerging resistance against these drugs makes it urgently necessary to discover and develop new, safe and, effective anti-infective agents. In this regard, the aim of this review is to highlight indole alkaloids from marine sources which have been shown to demonstrate activity against infectious diseases.

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Figures

Figure 1
Figure 1
Structures of β-carbolines with manzamine-type frameworks.
Figure 2
Figure 2
Structures of β-carbolines with eudistomin-derived scaffold and simple β-carbolines.
Figure 3
Figure 3
Structures of simple indole alkaloids.
Figure 4
Figure 4
Structures of bis-indole alkaloids.
Figure 5
Figure 5
Structures of ambiguine isonitriles.
Figure 6
Figure 6
Structures of fascaplysin and homofascaplysin A.
Figure 7
Figure 7
Structures of marinacarbolines and pendolmycin derivative.
Figure 8
Figure 8
Structure of indolocarbazole alkaloid staurosporine.
Figure 9
Figure 9
Structure of pyrazinoquinazoline-derived alkaloid oxoglyantrypine.
Figure 10
Figure 10
Structure of prenylated indole alkaloids (−)-stephacidin A.
Figure 11
Figure 11
Structures of heteroaromatic aaptamine-type indole alkaloids.
Figure 12
Figure 12
Structures of hyrtimomine-type alkaloids.
Figure 13
Figure 13
Structures of meridianins C and G.
Figure 14
Figure 14
Structures of hyrtioerectines D–F.
See this image and copyright information in PMC

References

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