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Review
. 2014:2014:824630.
doi: 10.1155/2014/824630. Epub 2014 Jun 5.

An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines

Bo Dong  1 , Dante S Zarlenga  2 , Xiaofeng Ren  1
Affiliations
Review

An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines

Bo Dong et al. J Immunol Res. 2014.

Abstract

Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. PRV has many nonessential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controlling viral infections in animals.

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Figures

Figure 1
Figure 1
Common sites in the PRV genome for inserting exogenous genes. The genes encoding TK, PK, gG, gD, gI, and gE are the most common sites for inserting exogenous sequences. The TK gene is located within the unique long region (UL), and the PK, gG, gD, gI and gE genes are located within the unique short region (US). IR = internal repeat sequences; TR = terminal repeat sequence. The drawing is not to scale.
See this image and copyright information in PMC

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