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. 1989 Jul;57(7):2246-8.
doi: 10.1128/iai.57.7.2246-2248.1989.

Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes

F G Araujo  1
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Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes

F G Araujo. Infect Immun. 1989 Jul.

Abstract

Mice injected with monoclonal antibody to the L3T4+ (CD4+) cell membrane surface glycoprotein of T lymphocytes and immunized with antigens of Trypanosoma cruzi had reduced antibody and cell-mediated immune responses to the organism. Mortality in these mice was 100% following challenge with 1.5 x 10(5) trypanosomes, whereas controls had a 50% survival rate, indicating that T-cell activation and viable L3T4+ (CD4+) T lymphocytes are essential for the development of resistance.

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References

    1. Parasitol Today. 1985 Jul;1(1):6-9 - PubMed
    1. J Immunol. 1987 Aug 1;139(3):919-26 - PubMed
    1. Trans R Soc Trop Med Hyg. 1988;82(1):84-9 - PubMed
    1. Eur J Immunol. 1987 Jul;17(7):1027-33 - PubMed
    1. Immunol Today. 1988 Sep;9(9):268-74 - PubMed

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