Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Jul 3;55(1):1-3.
doi: 10.1016/j.molcel.2014.06.022.

PML, SUMO, and RNF4: guardians of nuclear protein quality

Anne Gärtner  1 , Stefan Muller  2
Affiliations
Free article
Comment

PML, SUMO, and RNF4: guardians of nuclear protein quality

Anne Gärtner et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, Guo et al. (2014) report that misfolded or aggregated nuclear proteins, such as pathogenic polyQ proteins, are cleared by a SUMO-dependent quality control pathway, which involves the E3 SUMO ligase PML and the SUMO-targeted ubiquitin ligase RNF4.

PubMed Disclaimer

Comment on

LinkOut - more resources