Stem cells on alert: priming quiescent stem cells after remote injury

Zeenat Malam¹, Ronald D Cohn²

Affiliations

¹ Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
² Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Paediatrics and Molecular Genetics, University of Toronto, Toronto, ON M5R 0A3, Canada; Centre for Genetic Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: ronald.cohn@sickkids.ca.

PMID: 24996163
DOI: 10.1016/j.stem.2014.06.012

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Stem cells on alert: priming quiescent stem cells after remote injury

Zeenat Malam et al. Cell Stem Cell. 2014.

Free article

. 2014 Jul 3;15(1):7-8.

doi: 10.1016/j.stem.2014.06.012.

Authors

Zeenat Malam¹, Ronald D Cohn²

Affiliations

¹ Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
² Program in Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Paediatrics and Molecular Genetics, University of Toronto, Toronto, ON M5R 0A3, Canada; Centre for Genetic Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address: ronald.cohn@sickkids.ca.

PMID: 24996163
DOI: 10.1016/j.stem.2014.06.012

Abstract

A recent paper published by Rodgers et al. describes a novel phase of stem cell quiescence, termed GAlert, that serves to prime cells in response to injury-induced signals. These stem cells are located distal to the site of injury and require mTORC1 activity to elicit the alert response.

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mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).
Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA. Rodgers JT, et al. Nature. 2014 Jun 19;510(7505):393-6. doi: 10.1038/nature13255. Epub 2014 May 25. Nature. 2014. PMID: 24870234 Free PMC article.

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Stem cells on alert: priming quiescent stem cells after remote injury

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Stem cells on alert: priming quiescent stem cells after remote injury

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