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Practice Guideline
. 2014 Sep;67(9):751-7.
doi: 10.1136/jclinpath-2014-202467.

RAS testing of colorectal carcinoma—a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group

Newton A C S Wong, David Gonzalez, Manuel Salto-Tellez, Rachel Butler, Salvador J Diaz-Cano, Mohammad Ilyas, William Newman, Emily Shaw, Philippe Taniere, Shaun V Walsh; Association of Clinical Pathologists Molecular Pathology and Diagnostics Group
Practice Guideline

RAS testing of colorectal carcinoma—a guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Group

Newton A C S Wong et al. J Clin Pathol. 2014 Sep.

Abstract

Analysis of colorectal carcinoma (CRC) tissue for KRAS codon 12 or 13 mutations to guide use of anti-epidermal growth factor receptor (EGFR) therapy is now considered mandatory in the UK. The scope of this practice has been recently extended because of data indicating that NRAS mutations and additional KRAS mutations also predict for poor response to anti-EGFR therapy. The following document provides guidance on RAS (i.e., KRAS and NRAS) testing of CRC tissue in the setting of personalised medicine within the UK and particularly within the NHS. This guidance covers issues related to case selection, preanalytical aspects, analysis and interpretation of such RAS testing.

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