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. 2014 Jul 5:14:688.
doi: 10.1186/1471-2458-14-688.

Low birth weight and environmental tobacco smoke increases the risk of wheezing in adolescents: a retrospective cohort study

Meng-Hung Lin, James L Caffrey, Yu-Sheng Lin, Pau-Chung Chen, Ching-Chun Lin, Wen-Chao Ho  1 , Trong-Neng Wu, Ruey-Shiung Lin
Affiliations

Low birth weight and environmental tobacco smoke increases the risk of wheezing in adolescents: a retrospective cohort study

Meng-Hung Lin et al. BMC Public Health. .

Abstract

Background: Low birth weight (LBW) and environmental tobacco smoke (ETS) exposure are each associated with wheezing in children. This study was designed to examine the combined association of LBW and ETS with wheezing.

Methods: A retrospective birth cohort analysis linked with a national survey of allergic disorders among 1,018,031 junior high school students in Taiwan (1995-1996) was analyzed. The reported incidence of wheezing (yes or no) and ETS exposure (4 categories: 0, 1-20, 21-40 and greater than or equal to 41 household cigarettes per day) were obtained from validated questionnaires. Multiple logistic regression models were used to assess the associations of interest.

Results: There were 844,003 (83%) subjects analyzed after the exclusion criteria. LBW was associated with an increased risk of reporting ever wheezing (odds ratio [OR] = 1.08, 95% confidence interval [CI] = 1.01-1.16), current wheezing (OR = 1.09, 95% CI = 1.00-1.20) and wheezing with exercise (OR = 1.11, 95% CI = 1.02-1.21) within the smoke-free cohort. Higher ETS exposure correlated to a higher risk of wheezing (ever, current and with exercise). With ETS exposure, adolescents from the lowest birth weight cohorts were more likely to report wheezing (ever, current and with exercise).

Conclusions: ETS and LBW each has been related to increasing public health risk for respiratory symptoms among adolescents. Furthermore, LBW may aggravate the risk among those exposed to ETS. LBW, ETS and associated respiratory impairments may deserve special attention as part of a comprehensive environmental health risk assessment directed toward prevention and intervention.

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Schematic illustration of the study design.
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References

    1. Nepomnyaschy L, Reichman NE. Low birthweight and asthma among young urban children. Am J Public Health. 2006;96:1604–1610. - PMC - PubMed
    1. Seidman DS, Laor A, Gale R, Stevenson DK, Danon YL. Is low birth weight a risk factor for asthma during adolescence? Arch Dis Child. 1991;66:584–587. - PMC - PubMed
    1. Chilmonczyk BA, Salmun LM, Megathlin KN, Neveux LM, Palomaki GE, Knight GJ, Pulkkinen AJ, Haddow JE. Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. N Engl J Med. 1993;328:1665–1669. - PubMed
    1. Mackay D, Haw S, Ayres JG, Fischbacher C, Pell JP. Smoke-free legislation and hospitalizations for childhood asthma. N Engl J Med. 2010;363:1139–1145. - PubMed
    1. Kabir Z, Manning PJ, Holohan J, Keogan S, Goodman PG, Clancy L. Second-hand smoke exposure in cars and respiratory health effects in children. Eur Respir J. 2009;34:629–633. - PubMed

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