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. 2014 Nov;99(11):e218-21.
doi: 10.3324/haematol.2013.097220. Epub 2014 Jul 4.

Serum ferritin level and morbidity risk in transfusion-independent patients with β-thalassemia intermedia: the ORIENT study

Khaled M Musallam  1 , Maria Domenica Cappellini  2 , Shahina Daar  3 , Mehran Karimi  4 , Amal El-Beshlawy  5 , Giovanna Graziadei  2 , Matthew Magestro  6 , Jerome Wulff  7 , Guilhem Pietri  7 , Ali T Taher  8
Affiliations

Serum ferritin level and morbidity risk in transfusion-independent patients with β-thalassemia intermedia: the ORIENT study

Khaled M Musallam et al. Haematologica. 2014 Nov.
No abstract available

Keywords: complications; iron overload; thalassemia.

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Figures

Figure 1.
Figure 1.
(A) Annual mean serum ferritin level during the observation period. CI: confidence interval. (B) Kaplan-Meier survival curve with time to first morbidity by overall serum ferritin category. SF: serum ferritin level.
Figure 2.
Figure 2.
Morbidity occurrence during the 11-year observation period presented as a function of age and serum ferritin level category. Each bar represents a single patient. The bar starts at the patient’s base-line age, and represents serum ferritin level (≤300, >300 to <800, and ≥800 ng/mL) and number of new morbidities for every subsequent year, over the 11-year period. None of the patients had any morbidity at the start of observation.
See this image and copyright information in PMC

References

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    1. Musallam KM, Cappellini MD, Taher AT. Iron overload in β-thalassemia intermedia: an emerging concern. Curr Opin Hematol. 2013;20(3):187–92. - PubMed
    1. Musallam KM, Cappellini MD, Wood JC, Taher AT. Iron overload in non-transfusion-dependent thalassemia: a clinical perspective. Blood Rev. 2012;26 Suppl 1:S16–9. - PubMed
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    1. Taher AT, Viprakasit V, Musallam KM, Cappellini MD. Treating iron overload in patients with non-transfusion-dependent thalassemia. Am J Hematol. 2013;88(5):409–15. - PMC - PubMed

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