What׳s the role of sirolimus on the treatment of lymphangioleiomyomatosis (LAM)?: Merely tuning up of LAM-associated dysfunctional lymphatic vessels rather than cytoreduction?

Affiliations

¹ Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: ksuina@juntendo.ac.jp.
² Department of Human Pathology, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: tkhyz@juntendo.ac.jp.
³ Department of Human Pathology, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: m-kei@juntendo.ac.jp.
⁴ Department of Thoracic Surgery, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: kjsuzuki@juntendo.ac.jp.
⁵ Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: katakaha@juntendo.ac.jp.
⁶ Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan; The Study Group of Pneumothorax and Cystic Lung Diseases, 4-8-1 Seta, Setagaya-Ku, Tokyo 158-0095, Japan. Electronic address: kseyama@juntendo.ac.jp.

Comment

Kentaro Suina et al. Respir Investig. 2014 Jul.

. 2014 Jul;52(4):274-6.

doi: 10.1016/j.resinv.2014.02.004. Epub 2014 Apr 12.

¹ Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: ksuina@juntendo.ac.jp.
² Department of Human Pathology, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: tkhyz@juntendo.ac.jp.
³ Department of Human Pathology, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: m-kei@juntendo.ac.jp.
⁴ Department of Thoracic Surgery, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: kjsuzuki@juntendo.ac.jp.
⁵ Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan. Electronic address: katakaha@juntendo.ac.jp.
⁶ Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo 113-8421, Japan; The Study Group of Pneumothorax and Cystic Lung Diseases, 4-8-1 Seta, Setagaya-Ku, Tokyo 158-0095, Japan. Electronic address: kseyama@juntendo.ac.jp.

No abstract available

Comment on

Efficacy and safety of low-dose sirolimus for treatment of lymphangioleiomyomatosis.
Ando K, Kurihara M, Kataoka H, Ueyama M, Togo S, Sato T, Doi T, Iwakami S, Takahashi K, Seyama K, Mikami M. Ando K, et al. Respir Investig. 2013 Sep;51(3):175-83. doi: 10.1016/j.resinv.2013.03.002. Epub 2013 May 30. Respir Investig. 2013. PMID: 23978644