Ocular delivery of macromolecules

doi:10.1016/j.jconrel.2014.06.043

Review

. 2014 Sep 28:190:172-81.

doi: 10.1016/j.jconrel.2014.06.043. Epub 2014 Jul 3.

Ocular delivery of macromolecules

Yoo Chun Kim¹, Bryce Chiang², Xianggen Wu³, Mark R Prausnitz⁴

Affiliations

¹ School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
² Wallace Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA.
³ School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, China.
⁴ School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Wallace Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: prausnitz@gatech.edu.

PMID: 24998941
PMCID: PMC4142116
DOI: 10.1016/j.jconrel.2014.06.043

Review

Ocular delivery of macromolecules

Yoo Chun Kim et al. J Control Release. 2014.

. 2014 Sep 28:190:172-81.

doi: 10.1016/j.jconrel.2014.06.043. Epub 2014 Jul 3.

Authors

Yoo Chun Kim¹, Bryce Chiang², Xianggen Wu³, Mark R Prausnitz⁴

Affiliations

¹ School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
² Wallace Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA.
³ School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, Qingdao 266071, China.
⁴ School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Wallace Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: prausnitz@gatech.edu.

PMID: 24998941
PMCID: PMC4142116
DOI: 10.1016/j.jconrel.2014.06.043

Abstract

Biopharmaceuticals are making increasing impact on medicine, including treatment of indications in the eye. Macromolecular drugs are typically given by physician-administered invasive delivery methods, because non-invasive ocular delivery methods, such as eye drops, and systemic delivery, have low bioavailability and/or poor ocular targeting. There is a need to improve delivery of biopharmaceuticals to enable less-invasive delivery routes, less-frequent dosing through controlled-release drug delivery and improved drug targeting within the eye to increase efficacy and reduce side effects. This review discusses the barriers to drug delivery via various ophthalmic routes of administration in the context of macromolecule delivery and discusses efforts to develop controlled-release systems for delivery of biopharmaceuticals to the eye. The growing number of macromolecular therapies in the eye needs improved drug delivery methods that increase drug efficacy, safety and patient compliance.

Keywords: Barriers; Controlled release; Drug delivery; Eye; Macromolecules; Targeting.

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References

1. Ryu JK, Kim HS, Nam DH. Current status and perspectives of biopharmaceutical drugs. Biotechnol Bioprocess Eng. 2012;17:900–911.
1. Aggarwal RS. What’s fueling the biotech engine-2012 to 2013. Nat Biotechnol. 2014;32:32–39. - PubMed
1. Syed BA, Evans JB, Bielory L. Wet AMD market. Nat Rev Drug Discov. 2012;11:827. - PubMed
1. El Sanharawi M, Kowalczuk L, Touchard E, Omri S, de Kozak Y, Behar-Cohen F. Protein delivery for retinal diseases: from basic considerations to clinical applications. Prog Retin Eye Res. 2010;29:443–465. - PubMed
1. Kaur IP, Kakkar S. Nanotherapy for posterior eye diseases. J Control Release. 2014 - PubMed

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[1] Ryu JK, Kim HS, Nam DH. Current status and perspectives of biopharmaceutical drugs. Biotechnol Bioprocess Eng. 2012;17:900–911.

[2] Ryu JK, Kim HS, Nam DH. Current status and perspectives of biopharmaceutical drugs. Biotechnol Bioprocess Eng. 2012;17:900–911.

[3] Aggarwal RS. What’s fueling the biotech engine-2012 to 2013. Nat Biotechnol. 2014;32:32–39. - PubMed

[4] Aggarwal RS. What’s fueling the biotech engine-2012 to 2013. Nat Biotechnol. 2014;32:32–39. - PubMed

[5] Syed BA, Evans JB, Bielory L. Wet AMD market. Nat Rev Drug Discov. 2012;11:827. - PubMed

[6] Syed BA, Evans JB, Bielory L. Wet AMD market. Nat Rev Drug Discov. 2012;11:827. - PubMed

[7] El Sanharawi M, Kowalczuk L, Touchard E, Omri S, de Kozak Y, Behar-Cohen F. Protein delivery for retinal diseases: from basic considerations to clinical applications. Prog Retin Eye Res. 2010;29:443–465. - PubMed

[8] El Sanharawi M, Kowalczuk L, Touchard E, Omri S, de Kozak Y, Behar-Cohen F. Protein delivery for retinal diseases: from basic considerations to clinical applications. Prog Retin Eye Res. 2010;29:443–465. - PubMed

[9] Kaur IP, Kakkar S. Nanotherapy for posterior eye diseases. J Control Release. 2014 - PubMed

[10] Kaur IP, Kakkar S. Nanotherapy for posterior eye diseases. J Control Release. 2014 - PubMed

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Ocular delivery of macromolecules

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Ocular delivery of macromolecules

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