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Comparative Study
. 2014 Oct;116(3):205-14.
doi: 10.1016/j.cmpb.2014.05.008. Epub 2014 Jun 11.

Weighted comparison of two cumulative incidence functions with R-CIFsmry package

Jianing Li  1 , Jennifer Le-Rademacher  2 , Mei-Jie Zhang  1
Affiliations
Comparative Study

Weighted comparison of two cumulative incidence functions with R-CIFsmry package

Jianing Li et al. Comput Methods Programs Biomed. 2014 Oct.

Abstract

In this paper we propose a class of flexible weight functions for use in comparison of two cumulative incidence functions. The proposed weights allow the users to focus their comparison on an early or a late time period post treatment or to treat all time points with equal emphasis. These weight functions can be used to compare two cumulative incidence functions via their risk difference, their relative risk, or their odds ratio. The proposed method has been implemented in the R-CIFsmry package which is readily available for download and is easy to use as illustrated in the example.

Keywords: Competing risks; Cumulative incidence functions; Risk difference; Weighted comparison.

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Conflict of interest statement

Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Three alternative scenarios considered in simulation study
Figure 2
Figure 2
Cumulative incidence curves for cause 1 under the proportional subdistribution hazards alternative
Figure 3
Figure 3
Cumulative incidence curves with difference in the first two years
Figure 4
Figure 4
Cumulative incidence curves with difference after the first two years
Figure 5
Figure 5
Cumulative incidence of treatment-related mortality for the two platelet groups
Figure 6
Figure 6
Estimated TRM risk difference between high platelet group versus low platelet group
See this image and copyright information in PMC

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References

    1. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data. Wiley; New York: 2002.
    1. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Amer Statist Assoc. 1958;53:457–481.
    1. Cox DR. Regression models and life tables (with discussion) J Roy Statist Soc Ser B. 1972;34:187–220.
    1. Prentice RL, Kalbfleisch JD, Peterson AV, Flournoy N, Farewell VT, Breslow N. The analysis of failure time data in the presence of competing risks. Biometrics. 1978;34:541–554. - PubMed
    1. Cheng SC, Fine JP, Wei LJ. Prediction of cumulative incidence function under the proportional hazards model. Biometrics. 1998;54:219–228. - PubMed

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