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Review
. 2014:2014:318030.
doi: 10.1155/2014/318030. Epub 2014 Jun 5.

The role of microRNAs in the regulation of apoptosis in lung cancer and its application in cancer treatment

Norahayu Othman  1 , Noor Hasima Nagoor  2
Affiliations
Review

The role of microRNAs in the regulation of apoptosis in lung cancer and its application in cancer treatment

Norahayu Othman et al. Biomed Res Int. 2014.

Abstract

Lung cancer remains to be one of the most common and serious types of cancer worldwide. While treatment is available, the survival rate of this cancer is still critically low due to late stage diagnosis and high frequency of drug resistance, thus highlighting the pressing need for a greater understanding of the molecular mechanisms involved in lung carcinogenesis. Studies in the past years have evidenced that microRNAs (miRNAs) are critical players in the regulation of various biological functions, including apoptosis, which is a process frequently evaded in cancer progression. Recently, miRNAs were demonstrated to possess proapoptotic or antiapoptotic abilities through the targeting of oncogenes or tumor suppressor genes. This review examines the involvement of miRNAs in the apoptotic process of lung cancer and will also touch on the promising evidence supporting the role of miRNAs in regulating sensitivity to anticancer treatment.

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Figures

Figure 1
Figure 1
Scheme depicting up- and downregulated miRNAs and the roles they play in various biological pathways including apoptosis, proliferation, and angiogenesis.
Figure 2
Figure 2
Scheme depicting the roles miRNAs play in sensitivity and resistance to common cancer treatments.
See this image and copyright information in PMC

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