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Comment
. 2014 Jul;20(7):707-8.
doi: 10.1038/nm.3631.

Stressing out stem cells: linking stress and hematopoiesis in cardiovascular disease

Richard N Hanna  1 , Catherine C Hedrick  1
Affiliations
Comment

Stressing out stem cells: linking stress and hematopoiesis in cardiovascular disease

Richard N Hanna et al. Nat Med. 2014 Jul.

Abstract

Stress has long been thought to be a major contributing factor to cardiovascular disease, although little is known about the underlying cellular mechanisms. A new study illustrates that chronic stress promotes hematopoietic stem cell proliferation in bone marrow, leading to increased leukocyte production, circulation, and recruitment to the vasculature.

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Comment on

  • Chronic variable stress activates hematopoietic stem cells.
    Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M. Heidt T, et al. Nat Med. 2014 Jul;20(7):754-758. doi: 10.1038/nm.3589. Epub 2014 Jun 22. Nat Med. 2014. PMID: 24952646 Free PMC article.

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