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. 2014 Jul-Sep;20(3):194-206.
doi: 10.1179/2049396714Y.0000000067.

Angiotensin-converting enzyme gene polymorphisms and hypertension in occupational noise exposure in Egypt

Nermin Zawilla, Dalia Shaker, Amaal Abdelaal, Wael Aref

Angiotensin-converting enzyme gene polymorphisms and hypertension in occupational noise exposure in Egypt

Nermin Zawilla et al. Int J Occup Environ Health. 2014 Jul-Sep.

Abstract

Background: The gene-environment interaction in the pathogenesis of hypertension has not been extensively studied in occupational noise.

Objectives: The aim of this study was to determine the relationship between noise and hypertension in Egyptian workers, the interaction of angiotensin-converting enzyme (ACE) gene polymorphisms as modifiers, and the possible relationship between noise hearing impairment and hypertension.

Methods: Study subjects were divided into two groups depending on noise exposure level. The control group (n = 161) was exposed to noise intensity <85 dB and the exposed group (n = 217) was exposed to noise intensity ≧85 dB. A polymerase chain reaction was used to differentiate the various genotypes of ACE insertion/deletion (I/D) and ACE G2350A.

Results: Noise significantly increased the likelihood of hypertension. Carriers of the genotypes AG, GG, and DD were vulnerable to hypertension on noise exposure. No association between hypertension and hearing impairment or noise-induced hearing loss (NIHL) was found.

Conclusion: Our results support the association between ACE gene polymorphisms and occurrence of hypertension in noise-exposed workers.

Keywords: ACE G2350A gene,; ACE I/D gene,; Gene polymorphism occupational noise,; Genetic susceptibility,; Hypertension.

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Figures

Figure 1
Figure 1
G2350A genotypes. Lane (L): 50-bp ladder; lanes 1 and 2: AA genotype; lanes 3 and 4: GA genotype; and lane 5: GG genotype.
Figure 2
Figure 2
ACE genotypes. Lane (L): 50-bp ladder; lanes 2, 4, and 6: ID genotype; lanes 1, 3, and 5: DD genotype.
Figure 3
Figure 3
Correlation between duration of employment in the exposed group and systolic blood pressure.
Figure 4
Figure 4
Correlation between duration of employment in the exposed group and diastolic blood pressure.
See this image and copyright information in PMC

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