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. 2014 Oct;46(10):1997-2002.
doi: 10.1007/s11255-014-0779-x. Epub 2014 Jul 8.

Effect of continuous positive airway pressure on serum cystatin C among obstructive sleep apnea syndrome patients

Xiao-Bin Zhang  1 , Xing-Tang Jiang, Qi-Chang Lin, Xiao Chen, Hui-Qing Zeng
Affiliations

Effect of continuous positive airway pressure on serum cystatin C among obstructive sleep apnea syndrome patients

Xiao-Bin Zhang et al. Int Urol Nephrol. 2014 Oct.

Abstract

Purpose: The purpose of the present study was to evaluate the influence of continuous positive airway pressure (CPAP) on serum cystatin C, a novel biomarker of early renal impairment, among obstructive sleep apnea (OSA) patients.

Materials and methods: Newly diagnosed severe OSA patients who treated with CPAP for 3 months were enrolled from two sleep laboratories. Serum biomarkers of renal impairment, cystatin C, creatinine and estimated glomerular filtration rate (eGFR), were detected before and after CPAP treatment.

Results: A total of 39 severe OSA patients were enrolled, 29 (74.4 %) were male, and mean age was 51.2 ± 12.2 years. After CPAP treatment, there were no changes of creatinine and eGFR (77.80 ± 20.00 vs. 75.3 ± 16.60 and 98.69 ± 31.74 vs. 100.20 ± 28.30, all p > 0.05), but cystatin C declined significantly (0.87 ± 0.18 vs. 0.77 ± 0.21, p = 0.000).

Conclusion: CPAP can decrease cystatin C levels among severe OSA patients and may prevent the latent renal impairment.

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References

    1. Lung. 2006 Jan-Feb;184(1):43-9 - PubMed
    1. Chest. 2012 Jun;141(6):1422-1430 - PubMed
    1. Arch Intern Med. 1988 Jun;148(6):1337-40 - PubMed
    1. Chest. 2005 May;127(5):1674-9 - PubMed
    1. Int Urol Nephrol. 2012 Apr;44(2):607-17 - PubMed

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