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Comment

. 2014 Apr 28;15(4):114.

doi: 10.1186/gb4174.

Target competition: transcription factors enter the limelight

Florian A Karreth, Yvonne Tay, Pier Paolo Pandolfi

PMID: 25001290
PMCID: PMC4052382
DOI: 10.1186/gb4174

Comment

Target competition: transcription factors enter the limelight

Florian A Karreth et al. Genome Biol. 2014.

. 2014 Apr 28;15(4):114.

doi: 10.1186/gb4174.

Authors

Florian A Karreth, Yvonne Tay, Pier Paolo Pandolfi

PMID: 25001290
PMCID: PMC4052382
DOI: 10.1186/gb4174

Abstract

Transcription factor binding sites compete for a limited pool of bioavailable transcription factor molecules to fine tune gene expression.

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Figures

Figure 1
Target competition: a multi-layered regulatory mechanism. mRNAs crosstalk through miRNA sequestration resulting in co-expression. In addition, transcription factor mRNAs are translated into transcription factor proteins that can be competed for by transcription factor binding sites in promoters. Moreover, the target genes of such transcription factors are transcribed into RNA transcripts that may also participate in ceRNA crosstalk. TF, transcription factor.

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Comment on

The transcription factor titration effect dictates level of gene expression.
Brewster RC, Weinert FM, Garcia HG, Song D, Rydenfelt M, Phillips R. Brewster RC, et al. Cell. 2014 Mar 13;156(6):1312-1323. doi: 10.1016/j.cell.2014.02.022. Epub 2014 Mar 6. Cell. 2014. PMID: 24612990 Free PMC article.

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