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Comment
. 2014 Apr 28;15(4):114.
doi: 10.1186/gb4174.

Target competition: transcription factors enter the limelight

Florian A Karreth, Yvonne Tay, Pier Paolo Pandolfi
Comment

Target competition: transcription factors enter the limelight

Florian A Karreth et al. Genome Biol. .

Abstract

Transcription factor binding sites compete for a limited pool of bioavailable transcription factor molecules to fine tune gene expression.

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Figures

Figure 1
Figure 1
Target competition: a multi-layered regulatory mechanism. mRNAs crosstalk through miRNA sequestration resulting in co-expression. In addition, transcription factor mRNAs are translated into transcription factor proteins that can be competed for by transcription factor binding sites in promoters. Moreover, the target genes of such transcription factors are transcribed into RNA transcripts that may also participate in ceRNA crosstalk. TF, transcription factor.
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References

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