Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Sep;91(3):635-41.
doi: 10.4269/ajtmh.13-0627. Epub 2014 Jul 7.

Vector competence of Aedes aegypti and Aedes vittatus (Diptera: Culicidae) from Senegal and Cape Verde archipelago for West African lineages of chikungunya virus

Cheikh T Diagne  1 , Oumar Faye  1 , Mathilde Guerbois  1 , Rachel Knight  1 , Diawo Diallo  1 , Ousmane Faye  1 , Yamar Ba  1 , Ibrahima Dia  1 , Ousmane Faye  1 , Scott C Weaver  1 , Amadou A Sall  1 , Mawlouth Diallo  2
Affiliations

Vector competence of Aedes aegypti and Aedes vittatus (Diptera: Culicidae) from Senegal and Cape Verde archipelago for West African lineages of chikungunya virus

Cheikh T Diagne et al. Am J Trop Med Hyg. 2014 Sep.

Abstract

To assess the risk of emergence of chikungunya virus (CHIKV) in West Africa, vector competence of wild-type, urban, and non-urban Aedes aegypti and Ae. vittatus from Senegal and Cape Verde for CHIKV was investigated. Mosquitoes were fed orally with CHIKV isolates from mosquitoes (ArD30237), bats (CS13-288), and humans (HD180738). After 5, 10, and 15 days of incubation following an infectious blood meal, presence of CHIKV RNA was determined in bodies, legs/wings, and saliva using real-time reverse transcription-polymerase chain reaction. Aedes vittatus showed high susceptibility (50-100%) and early dissemination and transmission of all CHIKV strains tested. Aedes aegypti exhibited infection rates ranging from 0% to 50%. Aedes aegypti from Cape Verde and Kedougou, but not those from Dakar, showed the potential to transmit CHIKV in saliva. Analysis of biology and competence showed relatively high infective survival rates for Ae. vittatus and Ae. aegypti from Cape Verde, suggesting their efficient vector capacity in West Africa.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Amino acid sequences of the envelope 1 (E1) protein of chikungunya virus strains. Strains used for experimeental mosquito infections are underlined, and gray shading indicates epidemic chikungunya vieus of the East Central and South Africa lineage containing the A226V E1 substitution.
See this image and copyright information in PMC

References

    1. Weaver SC. Alphavirus infections. In: Guerrant RL, Walker DH, Weller PF, editors. Tropical Infectious Diseases: Principles, Pathogens, and Practice. Second edition. Philadelphia, PA: Elsevier Churchill Livingston; 2006. pp. 831–838.
    1. Chhabra M, Mittal V, Bhattacharya D, Rana UV, Lal S. Chikungunya fever: a re-emerging viral infection. Indian J Med Microbiol. 2008;26:5–12. - PubMed
    1. Krauss H, Weber A, Appel M, Enders B, Isenberg HD, Schiefer HG, Slenczka W, Graevenitz AV, Zahner H. Zoonoses: Infectious Diseases Transmissible from Animals to Humans. Third edition. Washington, DC: American Society for Microbiology Press; 2003.
    1. Renault P, Josseran L, Pierre V. Chikungunya related fatality rates, Mauritius, India, and Reunion Island. Emerg Infect Dis. 2008;14:1327. - PMC - PubMed
    1. Burt FJ, Rolph MS, Rulli NE, Mahalingam S, Heise MT. Chikungunya: a re-emerging virus. Lancet. 2012;379:662–671. - PubMed

Publication types

MeSH terms