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Randomized Controlled Trial
. 2014 Aug;134(2):e346-53.
doi: 10.1542/peds.2013-4257. Epub 2014 Jul 7.

Increasing provision of adolescent vaccines in primary care: a randomized controlled trial

Melissa B Gilkey  1 , Amanda M Dayton  2 , Jennifer L Moss  3 , Alicia C Sparks  3 , Amy H Grimshaw  2 , James M Bowling  3 , Noel T Brewer  4
Affiliations
Randomized Controlled Trial

Increasing provision of adolescent vaccines in primary care: a randomized controlled trial

Melissa B Gilkey et al. Pediatrics. 2014 Aug.

Abstract

Objectives: To assess the effectiveness of in-person and webinar-delivered AFIX (Assessment, Feedback, Incentives, and eXchange) consultations for increasing adolescent vaccine coverage.

Methods: We randomly assigned 91 primary care clinics in North Carolina, serving 107 443 adolescents, to receive no consultation or an in-person or webinar AFIX consultation. We delivered in-person consultations in April through May 2011 and webinar consultations in May through August 2011. The state's immunization registry provided vaccine coverage data for younger patients (ages 11-12 years) and older patients (ages 13-18 years) for 3 adolescent vaccines: tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap); meningococcal; and human papillomavirus (HPV) vaccines (≥1 dose, females only).

Results: At the 5-month follow-up, AFIX consultations increased vaccine coverage among younger adolescents. Patients in the in-person arm experienced coverage changes that exceeded those in the control arm for Tdap (3.4% [95% confidence interval (CI): 2.2 to 4.6]), meningococcal (4.7% [95% CI: 2.3 to 7.2], and HPV (1.5% [95% CI: 0.3 to 2.7]) vaccines. Patients in the webinar versus control arm also experienced larger changes for these vaccines. AFIX did little to improve coverage among older adolescents. At 1 year, the 3 arms showed similar coverage changes. The effectiveness of in-person and webinar consultations was not statistically different at either time point (all, P >.05).

Conclusions: Webinar AFIX consultations were as effective as in-person consultations in achieving short-term increases in vaccine coverage for younger adolescents. AFIX consultations for adolescents need improvement to have a stronger and more durable impact, especially for HPV vaccine.

Trial registration: ClinicalTrials.gov NCT01544764.

Keywords: North Carolina; adolescent health services; human papillomavirus infections/prevention and control; vaccination/statistics and numerical data.

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Figures

FIGURE 1
FIGURE 1
Flow diagram.
FIGURE 2
FIGURE 2
Vaccine coverage changes among adolescents ages 11 to 12 years at the (A) 5-month and (B) 1-year follow-up. Error bars show 95% CIs.
See this image and copyright information in PMC

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