Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jun 18;5(2):41-51.
eCollection 2014 Apr.

Heavy metals and pain in the dysfunctional patient

Carlo Di Paolo  1 , Emanuela Serritella  1 , Fabrizio Panti  1 , Giovanni Falisi  1 , Fedele Manna  1
Affiliations

Heavy metals and pain in the dysfunctional patient

Carlo Di Paolo et al. Ann Stomatol (Roma). .

Abstract

Aims: The aim of this research is to verify the quality and quantity of heavy metals (HM) of dental origin in TMD patients.

Methods: A population of 100 subject was studied and divided in two homogeneous groups: Study Group (SG) and Control Group (CG). Organism heavy metals were tested by a spot sampling method in which the first urine of the day, through Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), were analyzed. The results obtained were compared with reference values (RV) of Italian people. Descriptive statistical analysis and student's t-test has been applied (statistical significance for p > 0.05).

Results: The SG presented the absolute highest levels of HM compared to the CG (p=0.787). As regards the relation between pain and HM, the subjects that refer "severe/very severe" values of pain present the highest levels of HM in urines.

Conclusions: The obtained results seem to highlight a possible direct proportionality between the level of pain the increase of the concentration of heavy metals in all the examined groups and subgroups.

Keywords: TMD; heavy metals; pain.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Distribution of metals increased in SG (50 patients).
Figure 2
Figure 2
Distribution of metals increased in CG (50 patients).
Figure 3
Figure 3
Metals with significant percentage deviancy in prosthetic/orthodontic patients.
Figure 4
Figure 4
Hg amount in SG patients with amalgam fillings.
Figure 5
Figure 5
Metals – Articular problems.
Figure 6
Figure 6
Articular problems – Metals.
Figure 7
Figure 7
Metals – TMJ pain.
Figure 8
Figure 8
TMJ pain – Metals.
Figure 9
Figure 9
Metals - MM pain.
Figure 10
Figure 10
MM pain – Metals.
Figure 11
Figure 11
Metals – Headache.
Figure 12
Figure 12
Headache – Metals.
Figure 13
Figure 13
Metals – Cervicalgia.
Figure 14
Figure 14
Cervicalgia – Metals.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Cascone P, Di Paolo C. Patologia dell’articolazione temporomandibolare. UTET scienze mediche; 2004.
    1. Tanaka E, Detamore M, Mercuri L. Degenerative Disorders of the Temporomandibular Joint: Etiology, Diagnosis, and Treatment. J Dent Res. 2008;87(4):296–307. - PubMed
    1. de Bont LG, Dijkgraaf LC, Stegenga B. Epidemiology and natural progression of articular temporomandibular disorders. Oral Surgery Oral Medicine Oral Pathology. 1997;3 number 81. - PubMed
    1. de Bont LG. Management of Temporomandibular Joint Degenerative Diseases. Basel: Birkhäuser; 1996. Temporomandibular joint degenerative desease: pathogenesis; pp. 3–11.
    1. De Laat A. Temporomandibular Disorders as a source of orofacial pain. Acta neurol belg. 2011;101:26–31. - PubMed

LinkOut - more resources