Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jun 23:4:162.
doi: 10.3389/fonc.2014.00162. eCollection 2014.

AKR1C3 Inhibition Therapy in Castration-Resistant Prostate Cancer and Breast Cancer: Lessons from Responses to SN33638

Affiliations

AKR1C3 Inhibition Therapy in Castration-Resistant Prostate Cancer and Breast Cancer: Lessons from Responses to SN33638

Wen Zhou et al. Front Oncol. .
No abstract available

Keywords: 17β-estradiol; AKR1C3; SN33638; breast cancer; castration-resistant prostate cancer; testosterone.

PubMed Disclaimer

Comment on

  • A commentary on The activity of SN33638, an inhibitor of AKR1C3, on testosterone and 17β-estradiol production and function in castration-resistant prostate cancer and ER-positive breast cancer by Yin YD, Fu M, Brooke DG, Heinrich DM, Denny WA, Jamieson SMF. (2014). Front Oncol 4:159. doi: 10.3389/fonc.2014.00159

References

    1. Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer (2001) 1(1):34–45 10.1038/35094009 - DOI - PubMed
    1. Zhou W, Slingerland JM. Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy. Nat Rev Cancer (2014) 14(1):26–38 10.1038/nrc3622 - DOI - PubMed
    1. Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, et al. Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res (2008) 68:4447–54 10.1158/0008-5472.CAN-08-0249 - DOI - PMC - PubMed
    1. Sasano H, Miki Y, Nagasaki S, Suzuki T. In situ estrogen production and its regulation in human breast carcinoma: from endocrinology to intracrinology. Pathol Int (2009) 59:777–89 10.1111/j.1440-1827.2009.02444.x - DOI - PubMed
    1. Heinrich DM, Flanagan JU, Jamieson SM, Silva S, Rigoreau LJ, Trivier E, et al. Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3. Eur J Med Chem (2013) 62:738–44 10.1016/j.ejmech.2013.01.047 - DOI - PubMed