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. 2014 Jul 8;9(7):e101961.
doi: 10.1371/journal.pone.0101961. eCollection 2014.

The incidence and risk factors of meningitis after major craniotomy in China: a retrospective cohort study

Chen Chen  1 , Bingyan Zhang  1 , Shenglei Yu  1 , Feng Sun  1 , Qiaoling Ruan  1 , Wenhong Zhang  1 , Lingyun Shao  1 , Shu Chen  1
Affiliations

The incidence and risk factors of meningitis after major craniotomy in China: a retrospective cohort study

Chen Chen et al. PLoS One. .

Abstract

Background: Meningitis after neurosurgery can result in severe morbidity and high mortality. Incidence varies among regions and limited data are focused on meningitis after major craniotomy.

Aim: This retrospective cohort study aimed to determine the incidence, risk factors and microbiological spectrum of postcraniotomy meningitis in a large clinical center of Neurosurgery in China.

Methods: Patients who underwent neurosurgeries at the Department of Neurosurgery in Huashan Hospital, the largest neurosurgery center in Asia and the Pacific, between 1st January and 31st December, 2008 were selected. Individuals with only shunts, burr holes, stereotactic surgery, transsphenoidal or spinal surgery were excluded. The complete medical records of each case were reviewed, and data on risk factors were extracted and evaluated for meningitis.

Results: A total of 65 meningitides were identified among 755 cases in the study, with an incidence of 8.60%. The risk of meningitis was increased by the presence of diabetes mellitus (odds ratio [OR], 6.27; P = 0.009), the use of external ventricular drainage (OR, 4.30; P = 0.003) and the use of lumbar drainage (OR, 17.23; P<0.001). The isolated microorganisms included Acinetobacter baumannii, Enterococcus sp, Streptococcus intermedius and Klebsiella pneumonia.

Conclusions: Meningitis remains an important source of morbidity and mortality after major craniotomy. Diabetic patients or those with cerebral spinal fluid shunts carry significant high risk of infection. Thus, identification of the risk factors as soon as possible will help physicians to improve patient care.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Cumulative risk of drainage-associated meningitis.
EVD, external ventricular drainage; LD, lumbar drainage; Any drain, data included patients either with EVD or with LD.
See this image and copyright information in PMC

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