Review
doi: 10.1007/BF01990501.
The immunomodulatory effects of interferon-gamma on mature B-lymphocyte responses
Affiliations
- PMID: 2500358
- DOI: 10.1007/BF01990501
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Review
The immunomodulatory effects of interferon-gamma on mature B-lymphocyte responses
Experientia.
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Abstract
Interferon-gamma (IFN-gamma) exerts a broad spectrum of activities which affect the responses of mature B-cells. It strongly inhibits B-cell activation, acts as a B-cell growth factor (BCGF), and also induces final differentiation to immunoglobulin (Ig) production. IFN-gamma is deeply involved in the differential control of isotype expression, as it enhances IgG2a production and suppresses both IgG1 and IgE production. Although it is now possible to draw a general scheme of the effects of IFN-gamma on B-cells, a number of paradoxical results still exist in the field. In this manuscript, different experimental systems are analyzed in an attempt to explain these apparent paradoxes.
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