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. 2014 Apr;12(2):251-3.
doi: 10.1590/s1679-45082014rb2862.

Influence of gastric emptying on the control of postprandial glycemia: physiology and therapeutic implications

[Article in English, Portuguese]
Marcos Antonio Tambascia  1 , Domingos Augusto Cherino Malerbi  2 , Freddy Goldberg Eliaschewitz  3
Affiliations

Influence of gastric emptying on the control of postprandial glycemia: physiology and therapeutic implications

[Article in English, Portuguese]
Marcos Antonio Tambascia et al. Einstein (Sao Paulo). 2014 Apr.

Abstract
in English, Portuguese

The maintenance of glucose homeostasis is complex and involves, besides the secretion and action of insulin and glucagon, a hormonal and neural mechanism, regulating the rate of gastric emptying. This mechanism depends on extrinsic and intrinsic factors. Glucagon-like peptide-1 secretion regulates the speed of gastric emptying, contributing to the control of postprandial glycemia. The pharmacodynamic characteristics of various agents of this class can explain the effects more relevant in fasting or postprandial glucose, and can thus guide the individualized treatment, according to the clinical and pathophysiological features of each patient.

A manutenção da homeostase glicêmica é complexa e envolve, além da secreção e da ação da insulina e do glucagon, mecanismos hormonais e neurais, que regulam a taxa de esvaziamento gástrico. Esse mecanismo depende de fatores extrínsecos e intrínsecos. A secreção do peptídeo 1 semelhante ao glucagon regula a velocidade de esvaziamento gástrico, de modo a contribuir para o controle da glicemia pós-prandial. As características farmacodinâmicas dos diversos agentes dessa classe podem explicar os efeitos mais relevantes na glicemia de jejum ou pós-prandial e, portanto, podem orientar o tratamento individualizado, de acordo com as características clínicas e fisiopatológicas de cada paciente.

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