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Review
. 2014 Apr;12(2):256-8.
doi: 10.1590/s1679-45082014md2839.

Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

[Article in English, Portuguese]
Silmara Cristiane da Silveira Andreoli  1 , Nina Jardim Gasparini  1 , Gisele Pereira de Carvalho  2 , Bernardo Garicochea  3 , Robert Edward Pogue  1 , Rosângela Vieira de Andrade  1
Affiliations
Review

Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

[Article in English, Portuguese]
Silmara Cristiane da Silveira Andreoli et al. Einstein (Sao Paulo). 2014 Apr.

Abstract
in English, Portuguese

Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.

O câncer colorretal é o terceiro tipo de câncer mais comum em todo o mundo. A sobrevivência e o prognóstico dependem do estágio do tumor no diagnóstico, momento em que, em mais de 50% dos casos, o tumor já invadiu tecidos adjacentes ou ocorreu metástase. Objetivando-se melhorar o diagnóstico, o prognóstico clínico e o tratamento de pacientes com câncer colorretal, vários estudos investigaram microRNAs como marcadores moleculares da doença, devido à sua função reguladora potencial sobre genes supressores de tumor e oncogenes. Esta revisão procura resumir os principais tópicos relacionados ao uso de microRNAs no diagnóstico, na determinação do prognóstico clínico e na avaliação de resposta ao tratamento do câncer colorretal.

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Figures

Figure 1
Figure 1. Mechanisms of microRNA maturation
See this image and copyright information in PMC

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