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. 2014 Jun;62(6):699-701.
doi: 10.4103/0301-4738.136220.

Roles of elevated intravitreal IL-1β and IL-10 levels in proliferative diabetic retinopathy

Chunjie Mao, Hua Yan  1
Affiliations

Roles of elevated intravitreal IL-1β and IL-10 levels in proliferative diabetic retinopathy

Chunjie Mao et al. Indian J Ophthalmol. 2014 Jun.

Abstract

Purpose: To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR).

Materials and methods: Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA).

Results: Levels of IL-1β and IL-10 in vitreous were higher in PDR patients compared with control group. And there was significantly negative correlation between IL-1β and IL-10 in control group (r = -0.795; P = 0.032), whereas there was no significant correlation in PDR group (r = 0.176; P = 0.391).

Conclusion: Levels of IL-1β and IL-10 were upregulated in vitreous of PDR patients, and these two cytokines play roles in regulating the development and progression of PDR.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
The concentration of IL-1β an IL-10 between PDR group and control group. PDR = Proliferative diabetic retinopathy
Figure 2
Figure 2
The correlation between IL-1β and IL-10 in control group
See this image and copyright information in PMC

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