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Comment
. 2014 Jul;312(2):182-3.
doi: 10.1001/jama.2014.6336.

Antiepileptic drugs for neuropathic pain and fibromyalgia

Andrew Moore  1 , Philip Wiffen  1 , Eija Kalso  2
Affiliations
Comment

Antiepileptic drugs for neuropathic pain and fibromyalgia

Andrew Moore et al. JAMA. 2014 Jul.

Abstract

Clinical question: Are antiepileptic drugs associated with reduced pain intensity in patients with neuropathic pain or fibromyalgia?

Bottom line: In treating diabetic neuropathy and postherpetic neuralgia compared with placebo, gabapentin and pregabalin are associated with a modest increase in the number of patients experiencing meaningful pain reduction. In treating fibromyalgia, compared with placebo, pregabalin alone is associated with a small increase in the number of patients experiencing meaningful pain reduction. There is insufficient evidence for other antiepileptics.

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