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Case Reports
. 2014 Jan;35(1):79-82.
doi: 10.4103/0971-5851.133727.

Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review

M Sandhya Appachu  1 , Samit Purohit  1 , K C Lakshmaiah  1 , B S Aruna Kumari  2 , L Appaji  2
Affiliations
Case Reports

Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review

M Sandhya Appachu et al. Indian J Med Paediatr Oncol. 2014 Jan.

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients.

Keywords: Encephalopathy syndrome; PRES; steroid induced encephalopathy.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
This depicts a 5yr old patients T2w axial section at the level of basal ganglia showing illdefined hyperintensities in right parietooccipital, cortical and subcortical white matter
Figure 2
Figure 2
The same patients FLAIR sequence at the level of centrum semiovale shows subcortical hyperintensities in right frontal and bilateral parietooccipital regions with no evidence of diffusion restriction. The typical appearance and distribution of lesions suggests a possibility of PRESS
See this image and copyright information in PMC

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