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Review
. 2014 May;21(2):127-32.
doi: 10.11005/jbm.2014.21.2.127. Epub 2014 May 31.

Genetics of ossification of the posterior longitudinal ligament of the spine: a mini review

Shiro Ikegawa  1
Affiliations
Review

Genetics of ossification of the posterior longitudinal ligament of the spine: a mini review

Shiro Ikegawa. J Bone Metab. 2014 May.

Abstract

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease in aging populations and sometimes results in serious neurological problems due to compression of the spinal cord and nerve roots. OPLL is a multi-factorial (polygenic) disease controlled by genetic and environmental factors. Studies searching for the genetic component of OPLL, using linkage and association analyses, are in progress and several susceptibility genes have been reported. This paper reviews the recent progress in the genetic study of OPLL and comments on its future task.

Keywords: Genetic association studies; Ossification of posterior longitudinal ligament; Polymorphism.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

All authors state that they have no conflicts of interest.

References

    1. Matsunaga S, Sakou T. Overview of epidemiology and genetics. In: Yonenobu K, Nakamura K, Toyama Y, editors. Ossification of the posterior longitudinal ligament. 2nd ed. Tokyo: Springer; 2006. pp. 7–9.
    1. Matsunaga S, Sakou T. Ossification of the posterior longitudinal ligament of the cervical spine: etiology and natural history. Spine (Phila Pa 1976) 2012;37:E309–E314. - PubMed
    1. Saetia K, Cho D, Lee S, et al. Ossification of the posterior longitudinal ligament: a review. Neurosurg Focus. 2011;30:E1. - PubMed
    1. Ohtsuka K, Terayama K, Yanagihara M, et al. A radiological population study on the ossification of the posterior longitudinal ligament in the spine. Arch Orthop Trauma Surg. 1987;106:89–93. - PubMed
    1. Okawa A, Nakamura I, Goto S, et al. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet. 1998;19:271–273. - PubMed