Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014;121(3):259-65.
doi: 10.1007/s00702-013-1095-9.

Bacterial melanin increases electrical activity of neurons in Substantia Nigra pars compacta

T R Petrosyan, V A Chavushyan, A S Hovsepyan

Bacterial melanin increases electrical activity of neurons in Substantia Nigra pars compacta

T R Petrosyan et al. J Neural Transm (Vienna). 2014.

Abstract

Bacterial melanin (BM) has been used in different series of experiments as a neuroprotector. It facilitates recovery and regeneration processes after CNS lesions. The action of BM after Substantia Nigra destruction is of major interest. Electrophysiological study tries to reveal the effects of this substance on the electrical activity of Substantia Nigra pars compacta (SNc) neurons. The substance significantly increases the firing rate of SN cdopaminergic neurons. BM increases the rate of excitatory responses after high frequency tetanic stimulation of ipsilateral caudate–putamen. Overall increase in firing rate of SN neurons can contribute to recovery processes after neuronal degeneration in SN.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Neurotox Res. 2011 Jan;19(1):63-72 - PubMed
    1. Usp Fiziol Nauk. 2001 Apr-Jun;32(2):3-15 - PubMed
    1. Br J Pharmacol. 1990 Apr;99(4):731-5 - PubMed
    1. Neuroscience. 2004;129(2):481-9 - PubMed
    1. J Neurochem. 2006 Feb;96(4):909-16 - PubMed

LinkOut - more resources