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Comparative Study
. 2014 Aug 5;83(6):568-9.
doi: 10.1212/WNL.0000000000000675. Epub 2014 Jul 9.

LRRK2 parkinsonism in Tunisia and Norway: a comparative analysis of disease penetrance

Faycel Hentati  1 , Joanne Trinh  1 , Christina Thompson  1 , Ekaterina Nosova  1 , Matthew J Farrer  2 , Jan O Aasly  1
Affiliations
Comparative Study

LRRK2 parkinsonism in Tunisia and Norway: a comparative analysis of disease penetrance

Faycel Hentati et al. Neurology. .

Abstract

In recent years, the molecular etiology of parkinsonism has yielded to genetic analysis.1 Mutations in the gene leucine-rich repeat kinase 2 (LRRK2) have the highest genotypic and population attributable risk. Disparate penetrance estimates have been reported using a variety of statistical analyses, ethnic populations, and sample sizes.2 We compared the age-associated cumulative incidence (penetrance) of LRRK2 p.G2019S patients from Tunisia and Norway.

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Figures

Figure
Figure. Cumulative incidence of idiopathic Parkinson disease (A) and LRRK2 p.G2019S parkinsonism (B)
Kaplan-Meier analysis of parkinsonism with age at onset as the time variable. Black lines represent Tunisia and red lines represent Norway. Dotted lines represent confidence intervals. Unaffected LRRK2 p.G2019S carriers were right-censored.
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References

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