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Review
. 2014;16(2):92-4.

Immunoglobulin G4-related Retroperitoneal Fibrosis of the Pelvis

Anthony Dyer  1 , Peter M Sadow  2 , Erika Bracamonte  3 , Matthew Gretzer  1
Affiliations
Review

Immunoglobulin G4-related Retroperitoneal Fibrosis of the Pelvis

Anthony Dyer et al. Rev Urol. 2014.

Abstract

Retroperitoneal fibrosis (RPF) is a rare disease characterized by the replacement of normal tissue with fibrosis and/or inflammation. In this case, a 68-year-old man presented with RPF in the pelvis, a rare location for this disease. Biopsies were performed, which showed elevated levels of C-reactive protein, erythrocyte sedimentation rate, and, most importantly, immunoglobulin G4 (IgG4). It has been postulated that IgG4-related sclerosing disease is a systemic disease. Treatment has been successful with systemic corticosteroids.

Keywords: Retroperitoneal fibrosis; Serum immunoglobulin G4.

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Figures

Figure 1
Figure 1
Magnetic resonance imaging (MRI) of the pelvis at time of diagnosis (A) and after treatment course of high-dose corticosteroids (B). Diffuse thickening of the bladder (asterisk) and perivesical soft tissue (white arrow) has nearly completely resolved.
Figure 2
Figure 2
Diffuse acute and chronic inflammatory infiltrate of the bladder at 100 × (A) and 400 × (B) magnification. There is significant inflammatory response of periprostatic tissue (C), which stains extensively positive for immunoglobulin G4 (D).
See this image and copyright information in PMC

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