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. 2014 Jun 27:7:33.
doi: 10.1186/1755-7682-7-33. eCollection 2014.

Morphologic spectrum of glial tumors: an increased trend towards oligodendroglial tumors in Pakistan

Atif Ali Hashmi  1 , Naveen Faridi  1 , Babar Malik  2 , Muhammad Muzzammil Edhi  3 , Amna Khurshid  1 , Mehmood Khan  4
Affiliations

Morphologic spectrum of glial tumors: an increased trend towards oligodendroglial tumors in Pakistan

Atif Ali Hashmi et al. Int Arch Med. .

Abstract

Background: Glial tumors are most common brain tumors in our population. While the exact etiology and pathogenesis is unknown, the evaluation of current trends in the frequency and morphology of glial tumors is imperative to constitute better diagnostic and treatment protocols. Data pertaining to frequency and spectrum of glial tumors is scarcely available in our population. The aim of this study was to determine the morphologic spectrum of glial tumors prevalent in our population.

Method: 126 cases of glial tumors were retrospectively analyzed over a period of 5 years. Patients from all age groups and both genders were included in this study. Glial tumors were classified and graded according to WHO classification.

Results: Glial tumors were more common in males with a sex ratio of 2:1 and mean age of 38.26 years. Astrocytomas were most common glial tumors (51.6%) followed by oligodendrogliomas (23%). Glioblastoma was the most frequent astrocytic tumor and was incomparably frequent in older age group.

Conclusion: In our study, Oligodendrogliomas and mixed oligoastrocytomas represent major pattern of disease in comparison with available regional data. Knowledge of these changing trends and patterns of glial tumor morphology and frequency can help in improvements and applications of newly emerging diagnostic and treatment modalities.

Keywords: Astrocytoma; Glial tumors; Glioblastoma; Mixed oligoastrocytoma; Oligodendroglioma.

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Figures

Figure 1
Figure 1
Histologic types of glioma.
Figure 2
Figure 2
Oligodendroglioma WHO grade I, showing round nuclei with perinuclear halos and background chickenwire vasculature.
Figure 3
Figure 3
Anaplastic Oligodendroglioma, WHO grade III, showing greater nuclear atypia and mitotic activity with morphologic features compatable with Oligodendroglioma.
See this image and copyright information in PMC

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