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. 2014 Aug;8(2):459-463.
doi: 10.3892/etm.2014.1783. Epub 2014 Jun 12.

BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males

Linlin Tang  1 , Lingyan Wang  2 , Huadan Ye  3 , Xuting Xu  3 , Qingxiao Hong  3 , Hongwei Wang  4 , Leiting Xu  5 , Shizhong Bu  2 , Lina Zhang  5 , Jia Cheng  1 , Panpan Liu  6 , Meng Ye  6 , Yifeng Mai  6 , Shiwei Duan  1
Affiliations

BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males

Linlin Tang et al. Exp Ther Med. 2014 Aug.

Abstract

BCL11A is a critical modulator involved in hemoglobin switching. Recent studies have established an association between BCL11A gene polymorphisms and a risk of type 2 diabetes (T2D). The aim of the present study was to assess the correlation between BCL11A DNA methylation and T2D. A total of 48 T2D cases and 48 age- and gender-matched controls were recruited to evaluate BCL11A methylation using bisulfite pyrosequencing technology. Although no significant association was observed in BCL11A methylation between T2D patients and healthy controls (P=0.322), breakdown analysis by gender identified a significant association between BCL11A methylation and T2D in males (P=0.018). Notably, there was also a significant female-specific association between the mean BCL11A DNA methylation and triglyceride (TG) concentration (r=-0.34; P=0.019). The results indicated that BCL11A methylation contributed to the risk of T2D in males. In addition, BCL11A methylation may have an effect on the development of T2D by influencing TG metabolism. Thus, gender difference may provide new information to aid the understanding of T2D pathogenesis.

Keywords: BCL11A; CpG island; DNA methylation; gender; type 2 diabetes.

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Figures

Figure 1
Figure 1
Pairwise correlation of the methylation of the five CpGs on BCL11A.
Figure 2
Figure 2
Comparison of the mean DNA methylation levels between T2D cases and controls. T2D, type 2 diabetes.
Figure 3
Figure 3
Correlation between the mean BCL11A DNA methylation and TG levels. TG, triglyercide.
See this image and copyright information in PMC

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