Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jun 23:4:245.
doi: 10.7916/D84B2ZDF. eCollection 2014.

REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis

Abhimanyu Mahajan  1 , Liana S Rosenthal  1 , Charlene Gamaldo  1 , Rachel E Salas  1 , Gregory M Pontone  2 , Arita McCoy  1 , Chizoba Umeh  1 , Zoltan Mari  1
Affiliations

REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis

Abhimanyu Mahajan et al. Tremor Other Hyperkinet Mov (N Y). .

Abstract

Background: Parkinson's disease (PD) represents a major public health challenge that will only grow in our aging population. Understanding the connection between PD and associated prodromal conditions, such as rapid eye movement sleep behavioral disorder (RBD), is critical to identifying prevention strategies. However, the relationship between RBD and severity of motor findings in early PD is unknown. This study aims to examine this relationship.

Methods: The study population consisted of 418 PD patients who completed the Movement Disorders Society-United Parkinson's Disease Rating Scale (MDS-UPDRS) and rapid eye movement sleep (REM) disorder questionnaires at the baseline visit of the Michael J. Fox's Parkinson's Progression Markers Initiative (PPMI). Cross-sectional analysis was carried out to assess the association between REM Sleep Behavior Screening Questionnaire score and MDS UPDRS-3 (motor) score categories. Correlation with a higher score category was described as "worse motor findings". A score of 5 on the REM disorder questionnaire was defined as predictive of RBD.

Results: Out of the 418 PD patients, 113 (27.0%) had RBD. With univariate logistic regression analysis, individuals with scores predictive of RBD were 1.66 times more likely to have worse motor findings (p = 0.028). Even with age, gender, and Geriatric Depression Scale scores taken into account, individuals with scores predictive of RBD were 1.69 times more likely to have worse motor findings (p = 0.025).

Discussion: PD patients with RBD symptoms had worse motor findings than those unlikely to have RBD. This association provides further evidence for the relationship between RBD and PD.

Keywords: Movement Disorders Society-United Parkinson's Disease Rating Scale; Parkinson's disease; motor findings; rapid eye movement sleep.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interests: The authors report no conflict of interest.

Disclaimer: The views expressed in the submitted article by the authors are their own and not an official position of the institution or funder.

Figures

Figure 1
Figure 1. Distribution of Severity of Motor Symptoms in Participants with Likely RBD and unlikely RBD.
RBD, rapid eye movement sleep behavioral disorder.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Dorsey ER, Constantinescu R, Thompson JP, et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology. 2007;68:384–386. doi: 10.1212/01.wnl.0000247740.47667.03. - DOI - PubMed
    1. Parkinson's Outcome Project: Report to the Community. http://www.parkinson.org/NationalParkinsonFoundation/files/3f/3fea24f4-9....
    1. Postuma RB, Aarsland D, Barone P, et al. Identifying prodromal Parkinson's disease: Pre-motor disorders in Parkinson's disease. Mov Disord. 2012;27:617–626. doi: 10.1002/mds.24996. - DOI - PubMed
    1. [Sleep behavior disorder (RBD) in synucleionopaties] Glas Srp Akad Nauka Med. 2009;50:7–15. - PubMed
    1. Fulda S. Idiopathic REM sleep behavior disorder as a long-term predictor of neurodegenerative disorders. EPMA J. 2011;2:451–458. doi: 10.1007/s13167-011-0096-8. - DOI - PMC - PubMed

LinkOut - more resources