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Review
. 2015 Apr;30(4):564-74.
doi: 10.1093/ndt/gfu233. Epub 2014 Jul 10.

Interleukin-6 in renal disease and therapy

Simon A Jones  1 , Donald J Fraser  2 , Ceri A Fielding  3 , Gareth W Jones  3
Affiliations
Review

Interleukin-6 in renal disease and therapy

Simon A Jones et al. Nephrol Dial Transplant. 2015 Apr.

Abstract

Interleukin (IL)-6 has become a major target for clinical intervention in various autoimmune conditions. Here, drugs including the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab emphasize the clinical importance of IL-6 in driving disease and poor patient outcomes. During the course of this review, we will outline the biology surrounding IL-6 and discuss the impact of IL-6 in renal disease and the clinical complications associated with renal replacement therapies and transplantation. We will also consider the merit of IL-6 measurement as a prognostic indicator and provide a clinical perspective on IL-6-blocking therapies in renal disease.

Keywords: cytokines; interleukin-6; renal disease; therapy.

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