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Comment
. 2014 Jul 10;124(2):157-8.
doi: 10.1182/blood-2014-06-578922.

Case definition: postartemisinin delayed hemolysis

Paul M Arguin  1
Affiliations
Comment

Case definition: postartemisinin delayed hemolysis

Paul M Arguin. Blood. .

Abstract

In this issue of Blood, Jauréguiberry et al appear to have proven that the hypothesis of early destruction of pitted erythrocytes is correct and propose a method for screening patients for this syndrome. Early destruction of pitted erythrocytes has been the leading hypothesis for postartesunate delayed hemolysis since it was first recognized a few years ago.

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Conflict of interest statement

Conflict-of-interest disclosure: P.M.A. is the principal investigator for the Investigational New Drug Protocol: Intravenous Artesunate for Treatment of Severe Malaria in the United States, at the Centers for Disease Control and Prevention.

Figures

None
(Left) Malaria-infected erythrocytes. (Right) Parasites killed by artesunate have been removed by the spleen, resulting in a population of once-infected erythrocytes with a considerably decreased life span of about 7 to 21 days. Professional illustration by Patrick Lane, ScEYEnce Studios.
See this image and copyright information in PMC

Comment on

References

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