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. 2012;3(4):166-75.

Electrolytes Disturbance and Cyclosporine Blood Levels among Kidney Transplant Recipients

B Einollahi  1 , E Nemati  1 , Z Rostami  1 , M Teimoori  1 , A R Ghadian  1
Affiliations

Electrolytes Disturbance and Cyclosporine Blood Levels among Kidney Transplant Recipients

B Einollahi et al. Int J Organ Transplant Med. 2012.

Abstract

Background: Kidney transplantation is associated with various biochemical abnormalities such as changes in serum blood level of sodium (Na), potassium (K), calcium (Ca), and phosphorous (P). Although cyclosporine (CsA) is used commonly, the prevalence of its side effects, including electrolytes disturbance, is not well understood.

Objective: To find the prevalence of electrolytes disturbance and its relation to CsA blood levels.

Methods: In a retrospective study, 3308 kidney transplant recipients transplanted between 2008 and 2011 were studied. We evaluated the relation between serum Ca, P, Na, K and CsA trough (C0) and 2-hour post-dose (C2) levels.

Results: The mean±SD age of recipients was 37±15 years; 63% of patients were male. Overall, C2 levels had correlation with Ca blood level (p=0.018; OR: 1.13, 95%CI: 1.02-1.25), C0 levels had also correlation with blood levels of P and Cr (p<0.001; OR: 1.83, 95% CI: 1.59-2.11).

Conclusion: Electrolyte disturbances are prevalent. Higher serum levels of CsA can worsen the allograft function by disturbing the serum P and Ca levels.

Keywords: Cyclosporine; electrolytes; kidney; transplantation.

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Figures

Figure1
Figure1
Cyclosporine blood level at different calcium level
Figure 2
Figure 2
Cyclosporine blood level at different phosphorous level
Figure 3
Figure 3
Correlation between cyclosporine blood level and allograft function
See this image and copyright information in PMC

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