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Meta-Analysis
. 2014 Oct;24(10):1793-9.
doi: 10.1007/s11695-014-1359-y.

The effects of bariatric surgery on colorectal cancer risk: systematic review and meta-analysis

Sorena Afshar, Seamus B Kelly, Keith Seymour, Jose Lara, Sean Woodcock, John C Mathers
Meta-Analysis

The effects of bariatric surgery on colorectal cancer risk: systematic review and meta-analysis

Sorena Afshar et al. Obes Surg. 2014 Oct.

Abstract

Obesity is an established risk factor for colorectal cancer (CRC) but the effects of bariatric surgery on CRC incidence are uncertain. A systematic review of six electronic databases identified 3691 articles. Four observational studies met our inclusion criteria and results were pooled using a random effects model. Meta-analysis of these four studies revealed that bariatric surgery was associated with a significantly (p = 0.004) lower CRC incidence (RR = 0.73, 95 % confidence interval, 0.58 - 0.90) when compared with obese non-operated individuals, i.e., bariatric surgery is associated with a 27 % lower CRC risk. However the evidence base is limited and these findings should be confirmed by future studies with improved designs.

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