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. 1989 May;9(5):2247-50.
doi: 10.1128/mcb.9.5.2247-2250.1989.

Expression of raf oncogenes activates the PEA1 transcription factor motif

C Wasylyk  1 , B Wasylyk, G Heidecker, M Huleihel, U R Rapp
Affiliations

Expression of raf oncogenes activates the PEA1 transcription factor motif

C Wasylyk et al. Mol Cell Biol. 1989 May.

Abstract

PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that phosphorylation is somehow required.

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References

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